From: Chu, Tien-Min (firstname.lastname@example.org)
Date: Mon May 16 2005 - 21:59:15 EEST
3DP has been used for fabricating scaffolds from bioceramics and biodegradable polymers. Here is a list of papers published on scaffolds made by 3DP. I hope this helps.
1. Poly(L-lactide) (PLLA) (Giordano, Wu et al. 1996),
2. Poly (D.L-lactide-co-glycolide) (PLGA) (Kim, Utsunomiya et al. 1998; Park, Wu et al. 1998; Sherwood, Riley et al. 2002),
3. Hydroxyapatite (HA) (Dutta Roy, Simon et al. 2003; Yoo, Zhou et al. 2003),
4. Tricalcium phosphate (TCP) (Resnell, Shah et al. 2003),
5. PLGA/TCP (Sherwood, Riley et al. 2002; Roy, Simon et al. 2003; Simon, Roy et al. 2003)
6. Poly(desaminotyrosyl-tyrosine ethyl ester carbonate) (poly-(DTE carbonate) (Simon, Roy et al. 2003).
Dutta Roy, T., J. Simon, et al. (2003). Bone formation in 3D fabricated hydroxyapatite scaffolds with pores less than 100 microns. 29th Annual meeting of Society for Biomaterials, Reno, NV, Society for Biomaterials.
Giordano, R. A., B. M. Wu, et al. (1996). "Mechanical properties of dense polylactic acid structures fabricated by three dimensional printing." J Biomater Sci Polym Ed 8(1): 63-75.
Kim, S. S., H. Utsunomiya, et al. (1998). "Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels." Ann Surg 228(1): 8-13.
Park, A., B. Wu, et al. (1998). "Integration of surface modification and 3D fabrication techniques to prepare patterned poly(L-lactide) substrate allowing regionally selective cell adhesion." J Biomater Sci Polym Ed 9: 89-110.
Resnell, A., R. Shah, et al. (2003). In vitro characteriation of a bone void filler fabricated using TheriForm 3D Printing Technology. 29th Annual meeting of Society for Biomaterials, Reno, NV, Society for Biomaterials.
Roy, T. D., J. L. Simon, et al. (2003). "Performance of degradable composite bone repair products made via three-dimensional fabrication techniques." J Biomed Mater Res 66A(2): 283-91.
Sherwood, J. K., S. L. Riley, et al. (2002). "A three-dimensional osteochondral composite scaffold for articular cartilage repair." Biomaterials 23(24): 4739-51.
Simon, J. L., T. D. Roy, et al. (2003). "Engineered cellular response to scaffold architecture in a rabbit trephine defect." J Biomed Mater Res 66A(2): 275-82.
Yoo, J., M. Zhou, et al. (2003). Fabrication of biomaterial structures using a three dimensional printing technique. 29th Annual meeting of Society for Biomaterials, Reno, NV, Society for Biomaterials.
T Gabriel Chu
Dept. of Biomedical Engineering
Indiana Univ. Purdue Univ. Indianapolis
From: email@example.com [mailto:firstname.lastname@example.org] On Behalf Of Good, Jim
Sent: Monday, May 16, 2005 9:48 AM
To: Timothy J Gornet; email@example.com; firstname.lastname@example.org
Subject: RE: [rp-ml] Biodegradable polymers in RP?
I know that Joe Cesarano, from the Sandia Labs in Albuquerque, has worked
with HA in making lattice-type structures for medical purposes. He
developed the robocasting procedure which is an additive process using a
ceramic slurry or other slurries using powder materials. He has some
impressive parts made from different types of ceramics as well as some
Here is an excerpt from an article
Robotic Deposition of Hydroxyapatite Structures with Controlled Porosity for
the Improvement of Porous Bone Grafts
"Hydroxyapatite, the main mineral constituent of bone, has been used
successfully as a bone substitute material. Porous forms of hydroxyapatite
(HA) have shown excellent stability in vivo if pores are of an appropriate
size for bone cell ingrowth and vascularization.
The versatility of robocasting, a freeform fabrication technique that
robotically deposits ceramic suspensions, allows the fabrication of HA
structures with highly controlled novel internal architectures. Structures
with controlled pores on the size range of 100mm to 1000mm have been
produced with two different types of internal architecture. In contrast,
traditional methods of creating pores in HA offer limited control of the
pore architecture. The most common methods of porous HA are produced from
polymer spheres mixed with the HA powder or by the conversion of coral to
In Situ Fabrication and Repair (ISFR)
From: Timothy J Gornet [mailto:email@example.com]
Sent: Sunday, May 15, 2005 4:41 PM
To: firstname.lastname@example.org; email@example.com
Subject: Re: [rp-ml] Biodegradable polymers in RP?
There has also been work done with HA (hydroxyapetate sp?) in the past in
the SLS process.
Tim Gornet Manager, RP Operations
Rapid Prototyping Center
Vogt Bldg. Rm 101, University of Louisville, Louisville, KY 40292
Phone: (502)852-0714 FAX: (502)852-8890
>>> "Stacey Russell" <firstname.lastname@example.org> 05/14/05 11:41 AM >>>
Does anyone use biodegradable polymers in any RP process? I think they are
using polycaprolactone (PCL) in Asia at the National Technological U. Is
anyone in the U.S. doing anything comparable?
Biomedical Engineering & Biotechnology
University of Massachusetts Lowell
One University Avenue
Lowell, MA 01854
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